Copyright © 2004 Cascade BioScience, Inc. All rights reserved.
Thyroid hormone nuclear receptors (TRs) are ligand dependent members of the steroid/retinoic acid superfamily of transcription factors.The two genes encoding TRs identified to date,TR and TR, have been mapped to human chromosomes 17 and 3, respectively. TRs bind to thyroid hormone response elements (TREs) with half site binding motifs in the orientation of palindromes, direct repeats,or inverted palindromes.The affinities of binding are both variable and influenced differentially by 3,5,3'-triiodo-L-thyronine
(T-3).
